This research contrasts the environmental conditions, meteorological drivers, and air quality impacts of human‐ and lightning‐ignited wildfires in the southeastern and western United States, the two continental U.S. regions with the most wildfire burn area. We use the Fire Program Analysis Wildfire Occurrence Data (FPA FOD) to determine wildfire abundance and ignition sources between 1992 and 2015. We investigate specific ecoregions within these two U.S. regions and find that in the majority of ecoregions, annual lightning‐ and human‐ignited wildfire burn area have similar relationships with key meteorological parameters. We investigate the fuel moisture values where wildfires occur segregated by ignition type and show that within a given ecoregion, the differences in median fuel moisture between ignition types are generally smaller than the differences between ecoregions. Our results suggest that annual wildfire burn area for human‐ and lightning‐ignited wildfires within a given ecoregion are modulated by environmental conditions, and climate change may similarly impact wildfires of both ignition types. Finally, we estimate fine particulate matter emissions for Fire Program Analysis Wildfire Occurrence Data wildfires using the Fire INventory from NCAR model framework. We show that emissions of fine particulate matter from human‐ignited wildfires is significant and of a similar total magnitude between the west and southeastern United States. Additionally, the west and southeast have a similar number of wildfires associated with National Weather Service air quality smoke forecasts.