摘要：Seven anthraquinones including two new compounds namely capillasterquinones A and B ( 1 and 2 ) and one new butenolide namely capillasterolide ( 8 ) were isolated and structurally elucidated from the crinoid Capillaster multiradiatus . The inhibitory effect of compounds 1 – 8 on lipopolysaccharide (LPS)-induced nitric oxide (NO) production as well as inhibition of 1 on expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) proteins in RAW264.7 cells were also evaluated. As the obtained results, capillasterquinone A ( 1 ) showed strong NO production inhibitory activity with an IC50 of 5.89±0.11 µM. In addition, compound 1 reduced the LPS-induced iNOS and COX-2 expressions in a dose-dependent manner.
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