Mostly read and admired as a Depression writer, John Steinbeck enjoyed a high prestige in the world for his grand theme of humanity and ingenious craftsmanship. Different from other Depression writers, Steinbeck succeeds in making people keep a refreshing faith in humanity through devastation and desolation. This paper aims at analyzing Steinbeck’s humanistic concern in Of Mice and Men, through two main aspects, the desire for land and the hunger for intimacy. In the conclusion part, it is pointed out that beyond the gloom and despair, the dream for the paradise future and the quest for genuine human relations is always the noble ideal to seek; equality, benevolence and fraternity is forever the sublime Christian spirit calling people to return, though they’re lost in their direction for the time being, to their holy native land.