The first half of 20th century saw two translators coming from the west and east respectively choose the same translation strategy to carry out their syntactic experiments in their translation practice. The two renowned translators are Ezra Pound and Lu Xun. Staying in different historical contexts and encountered with the dominant target poetics they were dissatisfied with, both Pound and Lu Xun attempted to fulfill their syntactic experiments by signifying the syntactic differences of the source texts through the use of foreignization strategy. Although attracting many negative comments because of the unfluent translation resulting from them, Pound’ and Lu Xun’ syntactic experiments exert great influence on the development of their target languages, further contributing a lot to the development of their target culture. This paper will make a comparative study of Pound’s and Lu Xun’s syntactic experiments by exploring their motives, elaborating their translation principles and strategies, and analyzing their influence and significance.