Preservation effects of modified atmosphere package combined with nisin on fresh Atlantic salmon were evaluated. Farm-raised Atlantic salmon were purchased from the local market and packaged using either 19 % CO₂: 70 % N₂ : 11 % O₂ , 38 % CO₂ : 51 % N₂ : 11 % O₂, and under atmospheric air (with and without nisin at 400 IU/g) resulting in a total of 6 treatments. The microbiological ( aerobic plate count, psychrotrophic bacteria, and lactic acid bacteria) and the total volatile basic nitrogen analyses were evaluated on Day 0, 2, 4, 7 and 10. Package headspace and sensory evaluation were also conducted on Day 0, 2 and 4. The presence of CO₂ effectively inhibited the growth of all three types of bacteria while nisin significantly inhibited the growth of aerobic microorganisms with less impact on lactic acid bacteria . The TVB-N test indicated that CO₂ delayed the spoilage of Atlantic salmon while nisin had a lesser but measurable impact on Atlantic salmon shelf-life . The experiments support the potential for combining modified atmosphere package and nisin as an effective method to limit the spoilage of Atlantic salmon compare to traditional preservation methods.