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  • 标题:Comparison of Serum Free Testosterone, Luteinizing Hormone and Follicle Stimulating Hormone Levels in Diabetics and Non-Diabetics Men- a Case-Control Study
  • 作者:Rezvani, Mohammad Reza ; Saadatjou, Seyed Alireza ; Sorouri, Shahabaddin
  • 期刊名称:Journal of Research in Health Sciences
  • 印刷版ISSN:1682-2765
  • 出版年度:2012
  • 卷号:12
  • 期号:2
  • 页码:98-100
  • 语种:English
  • 出版社:Hamadan University of Medical Sciences
  • 摘要:Background: Diabetic men have been claimed to have lower serum free testosterone (FT) concentrations than non-diabetic men. The aim of this study was to investigate if serum FT, luteinizing hormone (LH), and follicle stimulating hormone (FSH) concentrations are different in patients with type 2 diabetes mellitus compared with healthy men and to identify factors associated with low serum testosterone concentrations in men with type 2 diabetes. Methods: Serum FT, LH and FSH concentrations in 65 men with type 2 diabetes between 50 and 55 years compared with 65 non-diabetic men in Valye-Asr Hospital in Birjand, Iran during October 2009 to August 2010. In addition, the relationships between serum FT concentrations with LH and FSH concentrations as well as other factors including age, fast blood sugar and glycemic control (HbA 1C ) were investigated. Results: Serum FT concentrations were significantly lower in type 2 diabetic patients (2.53±1.68 pg/ml) than in healthy men (4.29±2.43 pg/ml) ( P < 0.001). There were not any significant differences in LH and FSH concentrations between the two groups. There was a significant negative relationship between serum FT and HbA 1C , but this relation for LH and FSH was positive and non-significant ( P < 0.001). Conclusion: Serum FT concentration is lower in type 2 diabetic patients compared with non-diabetic men suggesting further research to better understand the underlying biologic mechanisms.
  • 其他摘要:Background: Diabetic men have been claimed to have lower serum free testosterone (FT) concentrations than non-diabetic men. The aim of this study was to investigate if serum FT, luteinizing hormone (LH), and follicle stimulating hormone (FSH) concentrations are different in patients with type 2 diabetes mellitus compared with healthy men and to identify factors associated with low serum testosterone concentrations in men with type 2 diabetes. Methods: Serum FT, LH and FSH concentrations in 65 men with type 2 diabetes between 50 and 55 years compared with 65 non-diabetic men in Valye-Asr Hospital in Birjand, Iran during October 2009 to August 2010. In addition, the relationships between serum FT concentrations with LH and FSH concentrations as well as other factors including age, fast blood sugar and glycemic control (HbA 1C ) were investigated. Results: Serum FT concentrations were significantly lower in type 2 diabetic patients (2.53±1.68 pg/ml) than in healthy men (4.29±2.43 pg/ml) ( P < 0.001). There were not any significant differences in LH and FSH concentrations between the two groups. There was a significant negative relationship between serum FT and HbA 1C , but this relation for LH and FSH was positive and non-significant ( P < 0.001). Conclusion: Serum FT concentration is lower in type 2 diabetic patients compared with non-diabetic men suggesting further research to better understand the underlying biologic mechanisms.
  • 关键词:Diabetes Mellitus;Type 2;Testosterone;Luteinizing Hormone;Follicle Stimulating Hormone
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