摘要：In our quest for structurally intriguing compounds from Korean medicinal plant sources, chromatographic separation of the 80% MeOH extract from Firmiana simplex resulted in the isolation and identification of three new lignan glycosides ( 1 – 3 ), together with six known lignan glycosides ( 4 – 9 ). The structures of 1 – 3 were determined on the basis of spectroscopic analyses, including extensive 2D-NMR and enzyme hydrolysis. Nitric oxide (NO) production was evaluated in the lipopolysaccharide-activated microglial cell line, BV-2 to investigate the anti-neuroinflammatory effects of the isolated compounds ( 1 – 9 ). Compound 7 marginally inhibited NO levels with IC50 values of 59.83 µM.
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