文章基本信息

标题：Determination of the Absolute Configuration of the Nabumetone Metabolite 4-(6-Methoxy-2-naphthyl)butan-2-ol Using the Chiral Derivatizing Agent, 1-Fluoroindan-1-carboxylic Acid
作者：Tomoyo Kamei ; Tomoyo Kamei ; Yuta Kimura 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：2019
卷号：67
期号：1
页码：75-78
DOI：10.1248/cpb.c18-00694
语种：English
出版社：The Pharmaceutical Society of Japan
摘要：The absolute configuration of (+)-4-(6-methoxy-2-naphthyl)butan-2-ol ((+)-MNBO), a nabumetone metabolite, was determined using 1-fluoroindan-1-carboxylic acid (FICA). Both enantiomers of the FICA methyl esters were derivatized to diastereomeric esters of (+)-MNBO by an ester exchange reaction. The results of ¹H- and ¹⁹F-NMR spectroscopy of the diastereomeric FICA esters of (+)-MNBO confirmed the absolute configuration of (+)-MNBO was ( S ).
关键词：absolute configuration;nabumetone metabolite;chiral derivatizing agent;1-fluoroindan-1-carboxylic acid;19F-NMR;1H-NMR