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  • 标题:Artopithecins A–D, Prenylated 2-Arylbenzofurans from the Twigs of Artocarpus pithecogallus and Their Tyrosinase Inhibitory Activities
  • 作者:Yong Wang ; Liu-Yun Xu ; Xi Liu
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2018
  • 卷号:66
  • 期号:12
  • 页码:1199-1202
  • DOI:10.1248/cpb.c18-00523
  • 语种:English
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Four new prenylated 2-arylbenzofurans, namely artopithecins A–D ( 1 – 4 ), together with five known compounds ( 5 – 9 ) were isolated from the twigs of Artocarpus pithecogallus for the first time. Their structures were elucidated based on extensive spectroscopic analysis and in comparison with literature data. All isolates were evaluated for their inhibitory activities against mushroom tyrosinase. Compounds 3 and 4 displayed significant tyrosinase inhibitory activities with IC50 values of 37.09±0.33 and 38.14±0.21 µM, respectively.
  • 关键词:Artocarpus pithecogallus;prenylated 2-arylbenzofuran;prenylflavonoid;chalcone;tyrosinase inhibitory activity
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