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  • 标题:Meniscal femoral and tibial surfaces characterization in the swine model.
  • 作者:Umberto Polito ; Mauro Di Giancamillo ; Giuseppe Michele Peretti
  • 期刊名称:International Journal of Health, Animal Science and Food Safety
  • 印刷版ISSN:2283-3927
  • 出版年度:2018
  • 卷号:5
  • 期号:1s
  • DOI:10.13130/2283-3927/10017
  • 语种:English
  • 出版社:Department of Health, Animal Science and Food Safety (VESPA)
  • 摘要:Menisci are wedge-like structures interposed, in the knee joint, between the femoral and the tibial articular heads (Kohn et al. 1995; Greis et al. 2002). Improving the articular surface, the cellular nutrition and the articular lubrication, they are essential structures for the prevention of gonarthrosis (Proctor et al.1989; Makris et al. 2011). This study is focused upon the relationship between the contact forces at the femoral and tibial surfaces and the corresponding structure of these meniscal surfaces. For this purpose, 20 adult (~9 months old) female pigs (Landrace x Large white, average weight 75–90 kg; n=80 meniscal samples) were obtained from a local slaughterhouse and dissected to isolate the menisci. Swine meniscal samples were evaluated from morphological (Safranin-O, Sirius Red and collagen type I and II) (Di Giancamillo et al. 2014), biochemical (DNA and glycosaminoglycans, or GAGs, contents) and biomechanical (compression and traction tests) points of view at the level of femoral and tibial meniscal surfaces. Results revealed a characterization of the meniscus which is biomechanical-dependent. The femoral surface, morphologically characterized by the interposition of radial and oblique fibers and biomechanically by the femoral condyles compression, sliding and rolling forces, shows a higher compressive modulus (p<0.05) and a greater amount of cells and GAGs deposition (p<0.01 for each analysis). On the other hand, results from traction test revealed a higher tensile modulus (p<0.05) in the tibial surface, characterized by a circumferential arrangement of the fibers and a poorer GAGs deposition and cellular distribution (p<0.01). Results (summarized in the figure 1) from this work suggest that a biphasic “femoral-to-tibial” scaffold that mimic the different behavior and composition of the two meniscal surfaces could be useful in the light of meniscal replacement.
  • 其他关键词:menisci; meniscus; swine model; biomechanics; scaffolds
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