Home oxygen therapy (HOT), also known as long-term oxygen therapy, is prescribed to patients with chronic respiratory failure (CRF) due to advanced respiratory diseases, as it has been shown to improve the prognosis of patients with chronic obstructive pulmonary disease (COPD). However, the therapeutic impact of HOT does not fully reflect the “socialization” of patients, which is one of the final goals of “comprehensive pulmonary rehabilitation”, proposed by the Japanese Respiratory Society. Since working is one form of socialization, we evaluated a 55-yr-old worker prescribed with HOT for the management of advanced COPD to elucidate and assess the social barriers experienced by HOT users. This case demonstrates a variety of factors affecting patients, respiratory physicians, occupational physicians, and management teams, which prevents patients from working. By elucidating these factors and seeking solutions, the promotion of the “harmonization of work with treatment and prevention” will both improve working environments and encourage CRF patients to continue working, leading to better socialization. Thus, the “harmonization of working with treatment and prevention” for CRF patients is a core goal for the promotion of both “health and productivity management” and “comprehensive pulmonary rehabilitation.”