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文章基本信息

  • 标题:Antioxidant Characterization and Biological Effects of Grape Pomace Extracts Supplementation in Caenorhabditis elegans
  • 作者:Begoña Ayuda-Durán ; Begoña Ayuda-Durán ; Susana González-Manzano
  • 期刊名称:Foods
  • 电子版ISSN:2304-8158
  • 出版年度:2019
  • 卷号:8
  • 期号:2
  • 页码:75
  • DOI:10.3390/foods8020075
  • 语种:English
  • 出版社:MDPI Publishing
  • 摘要:The aim of this work was to evaluate the biological activity of four grape pomace (GP) extracts that are rich in polyphenols using C. elegans as an in vivo model. Different concentrations of the GP extracts were assessed for their effects on the resistance of C. elegans against thermally induced oxidative stress, accumulation of reactive oxygen species (ROS), and lifespan. The cultivation of C. elegans with relatively low concentrations of GP extracts increased their resistance against thermal stress and prolonged their lifespan, while high levels displayed detrimental effects. In the studied extracts, maximum protection was observed for levels of polyphenols around 7 to 9 µg gallic acid equivalents per cultivation plate. The obtained results suggested that small changes in the ROS levels could have beneficial effects, although further studies are required to fully understand the impact of the extracts and assayed doses on ROS levels to explain the mechanism that is involved in the observed effects.
  • 关键词:grape pomace; C. elegans ; oxidative stress; ROS; lifespan; antioxidant activity grape pomace ; C. elegans ; oxidative stress ; ROS ; lifespan ; antioxidant activity
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