Alzheimer's disease (AD) related genes have been elucidated by advanced genetic techniques. Familial autosomal dominant AD genes founded by linkage analyses are APP , PSEN1 , PSEN2 , ABCA7 , and SORL1 . Genome-wide association studies have found risk genes such as ABCA7 , BIN1 , CASS4 , CD33 , CD2AP , CELF1 , CLU , CR1 , DSG2 , EPHA1 , FERMT2 , HLA-DRB5-HLA-DRB1 , INPP5D , MEF2C , MS4A6A/MS4A4E , NME8 , PICALM , PTK2B , SLC24A4 , SORL1 , and ZCWPW1 . ABCA7 , SORL1 , TREM2 , and APOE are proved to have high odds ratio (>2) in risk of AD using next generation sequencing studies. Thanks to the promising genetic techniques such as CRISPR-CAS9 and single-cell RNA sequencing opened a new era in genetics. CRISPR-CAS9 can directly link genetic knowledge to future treatment. Single-cell RNA sequencing are providing useful information on cell biology and pathogenesis of diverse diseases.