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文章基本信息

  • 标题:Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation
  • 本地全文:下载
  • 作者:Joon W. Shim ; Paul R. Territo ; Stefanie Simpson
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2019
  • 卷号:9
  • 期号:1
  • 页码:1-17
  • DOI:10.1038/s41598-018-37620-5
  • 出版社:Springer Nature
  • 摘要:in the cerebrospinal fluid of the severely hydrocephalic animals. Collectively, these results suggest that TMEM67 is required for the regulation of choroid plexus epithelial cell fluid and electrolyte homeostasis. The Wpk rat model, orthologous to human MKS3, provides a unique platform to study the development of both severe and mild hydrocephalus.
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