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  • 标题:Induction of human pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors
  • 本地全文:下载
  • 作者:Ken Hiratsuka ; Toshiaki Monkawa ; Tomohiko Akiyama
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2019
  • 卷号:9
  • 期号:1
  • 页码:1-13
  • DOI:10.1038/s41598-018-37485-8
  • 出版社:Springer Nature
  • 摘要:pretubular aggregates in another 2 days. Further culture in both 2-dimensional and 3-dimensional conditions produced iNephLOs containing cells characterized as podocytes, proximal tubules, and distal tubules in an additional 10 days. Global gene expression profiles showed similarities between iNephLOs and the human adult kidney, suggesting possible uses of iNephLOs as in vitro models for kidneys.
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