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  • 标题:Nebulized hypertonic saline triggers nervous system-mediated active liquid secretion in cystic fibrosis swine trachea
  • 本地全文:下载
  • 作者:Xiaojie Luan ; Julian S. Tam ; George Belev
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2019
  • 卷号:9
  • 期号:1
  • 页码:1-11
  • DOI:10.1038/s41598-018-36695-4
  • 出版社:Springer Nature
  • 摘要:swine ex-vivo tracheal preparations showed substantially decreased secretory response to HTS treatment after blockage of neuronal activity. Our results indicated that HTS-triggered ASL secretion is partially mediated by the stimulation of airway neurons and the subsequent activation of active epithelia secretion; osmosis accounts for only ~50% of the effect.
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