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  • 标题:Phosphorylation of nuclear Tau is modulated by distinct cellular pathways
  • 本地全文:下载
  • 作者:Giorgio Ulrich ; Agnese Salvadè ; Paul Boersema
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:17702
  • DOI:10.1038/s41598-018-36374-4
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:. We also report that the DNA damaging drug Etoposide increases the translocation of Tau to the nucleus whilst reducing its phosphorylation. We propose that overt phosphorylation of Tau, a hallmark of neurodegenerative disorders defined as tauopathies, may negatively regulate the function of nuclear Tau in protecting against DNA damage.
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