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  • 标题:OCT3 promoter haplotype is associated with metformin pharmacokinetics in Koreans
  • 本地全文:下载
  • 作者:Eun Young Kwon ; Jae-Yong Chung ; Hyo Jin Park
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:16965
  • DOI:10.1038/s41598-018-35322-6
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:by 17.2% and 15.9%, respectively [P = 0.016 and 0.031, GMR (90% CI) = 1.17 (1.06-1.29) and 1.17 (1.04-1.31), respectively], compared to the 20 subjects in the control group. Our study suggests that an OCT3 promoter haplotype affects the pharmacokinetics of metformin in Koreans as well as the OCT3 transcription rate.
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