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  • 标题:The geranyl acetophenone tHGA attenuates human bronchial smooth muscle proliferation via inhibition of AKT phosphorylation
  • 本地全文:下载
  • 作者:Hui Min Yap ; Yu Zhao Lee ; Hanis Hazeera Harith
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:16640
  • DOI:10.1038/s41598-018-34847-0
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:. The inhibitory effect of tHGA was demonstrated to be related to its direct inhibition of AKT phosphorylation, as well as inhibition of JNK and STAT3 signal transduction. Our findings highlight the anti-remodeling potential of this drug lead in chronic airway disease.
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