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  • 标题:Genetic enhancement of Ras-ERK pathway does not aggravate L-DOPA-induced dyskinesia in mice but prevents the decrease induced by lovastatin
  • 本地全文:下载
  • 作者:Irene Ruiz-DeDiego ; Stefania Fasano ; Oscar Solís
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:15381
  • DOI:10.1038/s41598-018-33713-3
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:mice. Altogether, these data suggest that ERK1/2-signaling activation in dyskinetic animals is maximal and does not require further genetic enhancement in the upstream Ras pathway. However, our data also demonstrate that such a genetic enhancement may reduce the efficacy of anti-dyskinetic drugs like lovastatin.
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