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  • 标题:Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils
  • 本地全文:下载
  • 作者:Yebin Zhou ; Ling-Ling An ; Raghothama Chaerkady
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:15228
  • DOI:10.1038/s41598-018-33385-z
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:/NCF2, as well as their dissociation from PAD4. This dissociation prevents the assembly of an active NADPH oxidase complex and an oxidative burst in neutrophils stimulated by phorbol-ester or immune complexes. In further support of a substrate-to-inactive enzyme interaction, small-molecule PAD inhibitors also disrupt the PAD4-NCF complex and reduce oxidase activation and phagocytic killing of Staphylococcus aureus. This novel role of PAD4 in the regulation of neutrophil physiology suggests that targeting PAD4 with active site inhibitors for the treatment of RA may have a broader impact on neutrophil biology than just inhibition of citrullination.
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