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  • 标题:Severity of local inflammation does not impact development of fibrosis in mouse models of intestinal fibrosis
  • 本地全文:下载
  • 作者:A. Hünerwadel ; S. Fagagnini ; G. Rogler
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:15182
  • DOI:10.1038/s41598-018-33452-5
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:and WT grafts. Severity of inflammation during onset of fibrogenesis did not correlate with collagen deposition. Although inflammation might be a pre-requisite for the initiation of fibrosis our data suggest that it has a minor impact on the progression of fibrosis. Our results suggest that development of fibrosis and inflammation may be disconnected. This may be important for explaining the inefficacy of anti-inflammatory treatments agents in most cases of fibrotic inflammatory bowel diseases (IBD).
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