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  • 标题:An optogenetic toolbox of LOV-based photosensitizers for light-driven killing of bacteria
  • 本地全文:下载
  • 作者:Stephan Endres ; Marcus Wingen ; Joaquim Torra
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:15021
  • DOI:10.1038/s41598-018-33291-4
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:, all of the other tested flavoproteins were able to produce singlet oxygen and/or hydrogen peroxide but exhibited remarkable differences in ROS selectivity and yield. Accordingly, most LOV-FPs are potent photosensitizers, which can be used for light-controlled killing of bacteria. Furthermore, the two variants Pp2FbFP and DsFbFP M49I, exhibiting preferential photosensitization of singlet oxygen or singlet oxygen and superoxide, respectively, were shown to be new tools for studying specific ROS-induced cell signaling processes. The tested LOV-FPs thus further expand the toolbox of optogenetic sensitizers usable for a broad spectrum of microbiological and biomedical applications.
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