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文章基本信息

  • 标题:Identification of novel acetylcholinesterase inhibitors designed by pharmacophore-based virtual screening, molecular docking and bioassay
  • 本地全文:下载
  • 作者:Cheongyun Jang ; Dharmendra K. Yadav ; Lalita Subedi
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:14921
  • DOI:10.1038/s41598-018-33354-6
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:value of compounds 5c and 6a presented selective inhibition of AChE without inhibiting butyrylcholinesterase (BChE) at uM level. Molecular docking studies were performed to explain the potent AChE inhibition of the target compounds studies to explain high affinity.
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