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  • 标题:Anxa4 mediated airway progenitor cell migration promotes distal epithelial cell fate specification
  • 本地全文:下载
  • 作者:Kewu Jiang ; Zan Tang ; Juan Li
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:14344
  • DOI:10.1038/s41598-018-32494-z
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:airway epithelial cells exhibit a "lag-behind" behavior and tend to stay at the stalk airways. Moreover, we found that Anxa4-overexpressing cells tend to migrate to the bud tips. Finally, we demonstrated that Anxa4 functions redundantly with Anxa1 and Anxa6 in regulating endoderm budding process. Our study demonstrates that ERK1/2/Anxa4 signaling plays a role in promoting the migration of airway epithelial progenitor cells to distal airway tips and ensuring their distal cell fate.
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