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  • 标题:In vitro performances of novel co-spray-dried azithromycin/rifampicin microparticles for Rhodococcus equi disease treatment
  • 本地全文:下载
  • 作者:Elisa Rampacci ; Maria Luisa Marenzoni ; Elisabetta Chiaradia
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:12149
  • DOI:10.1038/s41598-018-30715-z
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:values of >100 mg/L supported low cytotoxicity of drug combinations and the combination index suggested an antagonistic toxic effect. Co-spray-drying enhanced powder dispersibility and solubility, which may improve bioavailability as well as provide administration alternatives. The novel AZM/RIF MP combinations could result a valid platform to develop new treatment strategies against R. equi infections in animals and humans.
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