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  • 标题:High Dose Vitamin D supplementation alters faecal microbiome and predisposes mice to more severe colitis
  • 本地全文:下载
  • 作者:Simon Ghaly ; Nadeem O. Kaakoush ; Frances Lloyd
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:11511
  • DOI:10.1038/s41598-018-29759-y
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:levels reduced by 63% in the D++ group and 23% in the D+ group after 6 days of DSS treatment. Thus, high dose vitamin D supplementation is associated with a shift to a more inflammatory faecal microbiome and increased susceptibility to colitis, with a fall in circulating vitamin D occurring as a secondary event in response to the inflammatory process.
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