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  • 标题:Decreased signalling of EphA4 improves functional performance and motor neuron survival in the SOD1G93A ALS mouse model
  • 本地全文:下载
  • 作者:J. Zhao ; L. T. Cooper ; A. W. Boyd
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:11393
  • DOI:10.1038/s41598-018-29845-1
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:mice promoted significant improvement in functional performance during the disease course and a delay in disease onset relative to control mice. Importantly, mice in the heterozygous deletion group showed significantly improved survival of motor neurons and architecture of endplates of neuromuscular junctions compared with control and homozygous EphA4-deletion groups. Our novel results show that EphA4 signalling directly regulates motor neuron survival and that mutEphA4-Fc is a promising therapeutic candidate to slow disease progression in ALS.
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