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  • 标题:Defining the frequency of human papillomavirus and polyomavirus infection in urothelial bladder tumours
  • 本地全文:下载
  • 作者:Matthew A. Llewellyn ; Naheema S. Gordon ; Ben Abbotts
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:11290
  • DOI:10.1038/s41598-018-29438-y
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:s we were able to confirm that 23 were BKV and 6 were JCV by Sanger sequencing. Polyomavirus large T antigen expression was low but detectable in 70% of the sequencing-confirmed polyomavirus positive samples. Thus, in United Kingdom patients, the presence of HPV DNA sequences is extremely rare in UBC (<1% of cases). Polyomavirus DNA (predominantly BKV) is more common in UBC, but still only detectable in 7% of cases and in many of these cases at low copy number. We have performed the largest virus screening to date in UBC, finding that HPV16, HPV18 and HPyV are unlikely to be common causative agents in UBC.
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