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  • 标题:Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways
  • 本地全文:下载
  • 作者:Hadar Vinograd-Byk ; Paul Renbaum ; Ephrat Levy-Lahad
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:11265
  • DOI:10.1038/s41598-018-29215-x
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:cortex predicts novel roles for VRK1 in neuronal pathways including neurotrophin signaling, axon guidance and pathways implicated in the pathogenesis of ALS. Together, our studies of the partial KO Vrk1 mice reveal that even moderately reduced levels of Vrk1 expression result in minor neurological impairment and indicate new neuronal pathways likely involving VRK1.
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