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  • 标题:A VSV-based Zika virus vaccine protects mice from lethal challenge
  • 本地全文:下载
  • 作者:Jackson Emanuel ; Julie Callison ; Kimberly A. Dowd
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:11043
  • DOI:10.1038/s41598-018-29401-x
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:mice and resulted in uniform protection when a single dose was administered 28 days prior to lethal challenge. Furthermore, this vaccine is fast-acting and can uniformly protect mice from lethal disease when administered as late as 3 days prior to ZIKV challenge. Thus, VSV-ZIKV vectors are promising vaccine candidates and should move forward along the licensure pathway.
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