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  • 标题:Hydrolysis of Extracellular Pyrophosphate increases in post-hemodialysis plasma
  • 本地全文:下载
  • 作者:Daniel Azpiazu ; Emilio González-Parra ; Jesús Egido
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:11089
  • DOI:10.1038/s41598-018-29432-4
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:, 7.2 µmol/L), reducing pyrophosphate hydrolysis in plasma and increasing plasma pyrophosphate availability. Alkaline phosphatase is also found in many tissues and cells types; therefore, our results in plasma may be indicative of changes in phosphatase activity in other locations that collectively could contribute significantly to pyrophosphate hydrolysis in vivo. In conclusion, these findings demonstrate that dialysis increases pyrophosphate hydrolysis, which, taken together with previously reported increases in alkalization and calcium ion levels in post-dialysis plasma, causes VC and could be prevented by adding calcification inhibitors during dialysis.
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