摘要：People in a social group often have to make decisions under conflict, for instance, to conform to the group or obey authority (subjects at higher social rank in the group). The neural mechanisms underlying how social group setting affects decision-making have largely remained unclear. In this study, we designed novel behavioral tests using food access priority and fear conditioning paradigms that captured decision-making under conflict associated with social group environments in mice and examined the roles of serotonin (5-HT) on these processes. Using these behavioral tests, administration of the selective 5-HT reuptake inhibitor, which increased 5-HT transmission, was found to attenuate conflicts in decision-making that may be associated with human cases of social obedience and conformity in mice under group housing. The results suggest that 5-HT plays important roles in the regulation of individual behaviors that organize social group dynamics.
