摘要：The localization of object position in space is one of the most important visual abilities in humans. Motion-induced position shift is a perceptual illusion in which the position of a moving object is perceived to be shifted in the direction of motion. In this study, we wanted to explore whether and how Alzheimer's disease (AD) affects this illusion. We recruited a group of patients with early AD and a group of age-matched healthy controls. In our experiments, two drifting Gabor patches moving in opposite directions were presented and participants were asked to report whether the upper Gabor appeared rightwards or leftwards of the lower one. We measured the psychometric functions, of which the point of subjective alignment was taken as the magnitude of motion-induced position shift. We compared the position shift across the two groups at three different retinal eccentricities. We found that position shifts were systematically smaller in the AD group as comparing to the elderly control group. Our data demonstrated that AD patients were less prone to motion-induced position shift. The results add to the existing knowledge of perceptual deficits in AD patients. We suggest that motion induced position shift may be effective as a new behavioral indicator for AD identification.
