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  • 标题:Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly
  • 本地全文:下载
  • 作者:Pénélope A. Andreux ; Marcus P. J. van Diemen ; Maxime R. Heezen
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:8548
  • DOI:10.1038/s41598-018-26944-x
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:P-MRS) and a comprehensive set of biological biomarkers were measured ex vivo in vastus lateralis muscle biopsies. In pre-frail subjects, phosphocreatine recovery was impaired and mitochondrial respiratory complex protein and activity levels were significantly lower when compared with active elderly. Analysis of microarray data showed that mitochondrial genes were also significantly down-regulated in muscle of pre-frail compared to active elderly. These results show that mitochondrial impairment is a hallmark of pre-frailty development and the onset of decline in muscle function in the elderly.
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