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  • 标题:Birth weight variants are associated with variable fetal intrauterine growth from 20 weeks of gestation
  • 本地全文:下载
  • 作者:L. Engelbrechtsen ; D. Gybel-Brask ; Y. Mahendran
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:8376
  • DOI:10.1038/s41598-018-26752-3
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:), corresponding to a mean difference of 410 g at 40 weeks of gestation between a child with lowest and highest GRS. Eight variants were independently associated with intrauterine growth throughout the pregnancy, while four variants were associated with fetal growth in the periods 20-25 or 25-32 weeks of gestation, indicating that some variants may act in specific time windows during pregnancy. Four of the intrauterine growth variants were associated with type 2 diabetes, hypertension or BMI in the UK Biobank, which may provide basis for further understanding of the link between intrauterine growth and later risk of metabolic disease.
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