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  • 标题:Excitation and injury of adult ventricular cardiomyocytes by nano- to millisecond electric shocks
  • 本地全文:下载
  • 作者:Iurii Semenov ; Sergey Grigoryev ; Johanna U. Neuber
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:8233
  • DOI:10.1038/s41598-018-26521-2
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:transients, although repeated ns shocks often evoke abnormal responses, (2) Stimulation thresholds expectedly increase as the shock duration decreases, similarly for VCMs from different species, (3) Stimulation threshold energy is minimal for the shortest shocks, (4) VCM orientation with respect to the electric field does not affect the threshold for ns shocks, and (5) The shortest shocks cause the least electroporation injury. These findings support further exploration of ns defibrillation, although abnormal response patterns to repetitive ns stimuli are of a concern and require mechanistic analysis.
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