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  • 标题:Mesenchymal stem cells and T cells in the formation of Tertiary Lymphoid Structures in Lupus Nephritis
  • 本地全文:下载
  • 作者:S. Esmaeil Dorraji ; Aud-Malin K. Hovd ; Premasany Kanapathippillai
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:7861
  • DOI:10.1038/s41598-018-26265-z
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:T cells, but an inhibitory effect was observed when in co-culture with non-stimulated MSCs. A contact dependent increase in Th2 and Th17 subsets were observed for T cells from the Healthy group after co-culture with stimulated MSCs. Our data suggest that tissue-specific or/and migratory MSCs could have pivotal roles as LTo cells in accelerating early inflammatory processes and initiating the formation of kidney specific TLS in chronic inflammatory conditions.
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