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  • 标题:FACS-Seq analysis of Pax3-derived cells identifies non-myogenic lineages in the embryonic forelimb
  • 本地全文:下载
  • 作者:Arun J. Singh ; Chih-Ning Chang ; Hsiao-Yen Ma
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:7670
  • DOI:10.1038/s41598-018-25998-1
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:cells to construct gene networks involved in different stages of embryonic and fetal development. With this, we identified genes involved in the skeletal, muscular, vascular, nervous and immune systems. Expression of genes related to the immune, skeletal and vascular systems showed prominent increases over time, suggesting a non-skeletal myogenic context of Pax3-derived cells. Using co-expression analysis, we observed an immune-related gene subnetwork active during fetal myogenesis, further implying that Pax3-derived cells are not a strictly myogenic lineage, and are involved in patterning and three-dimensional formation of the forelimb through multiple systems.
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