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  • 标题:Gestational oral low-dose estradiol-17β induces altered DNA methylation of CDKN2D and PSAT1 in embryos and adult offspring
  • 本地全文:下载
  • 作者:Vera A. van der Weijden ; Veronika L. Flöter ; Susanne E. Ulbrich
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:7494
  • DOI:10.1038/s41598-018-25831-9
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:liver. Whereas blastocysts showed hypomethylation, the liver of 1-year old offspring showed subtle, but significant hypermethylation. We show that the level of effect of estrogenic EDC, with the periconceptual period as a sensitive time window, is at much lower concentration than currently presumed and propose epigenetics as a sensitive novel risk assessment parameter.
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