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  • 标题:(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis
  • 本地全文:下载
  • 作者:Diana Macedo ; Carolina Jardim ; Inês Figueira
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:6965
  • DOI:10.1038/s41598-018-25118-z
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:toxicity in yeast and human cells, improving viability by reducing aSyn aggregation and inducing its clearance. In addition, LPDMs modulated pathways associated with aSyn toxicity, such as oxidative stress, endoplasmic reticulum (ER) stress, mitochondrial impairment, and SIR2 expression. Overall, LPDMs reduced aSyn toxicity, enhanced the efficiency of ER-associated protein degradation by the proteasome and autophagy, and reduced oxidative stress. In total, our study opens novel avenues for the exploitation of (poly)phenols in nutrition and health.
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