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  • 标题:In vivo Dynamic Phase-Contrast X-ray Imaging using a Compact Light Source
  • 本地全文:下载
  • 作者:Regine Gradl ; Martin Dierolf ; Benedikt Günther
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:6788
  • DOI:10.1038/s41598-018-24763-8
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:We describe the first dynamic and the first in vivo X-ray imaging studies successfully performed at a laser-undulator-based compact synchrotron light source. The X-ray properties of this source enable time-sequence propagation-based X-ray phase-contrast imaging. We focus here on non-invasive imaging for respiratory treatment development and physiological understanding. In small animals, we capture the regional delivery of respiratory treatment, and two measures of respiratory health that can reveal the effectiveness of a treatment; lung motion and mucociliary clearance. The results demonstrate the ability of this set-up to perform laboratory-based dynamic imaging, specifically in small animal models, and with the possibility of longitudinal studies.
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