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  • 标题:Development of a Click-Chemistry Reagent Compatible with Mass Cytometry
  • 本地全文:下载
  • 作者:Jessica Shaklee ; Kriti Srivastava ; Heather Brown
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:6657
  • DOI:10.1038/s41598-018-25000-y
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Tb makes it possible to measure DNA synthesis in single cells using mass cytometry. The approach introduced here shows similar sensitivity (true positive rate) to other methods used to measure DNA synthesis in single cells by mass cytometry and is compatible with the parallel antibody-based detection of other parameters in single cells. Due to its universal nature, the use of click-chemistry in mass cytometry expands the types of molecular targets that can be monitored by mass cytometry.
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