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  • 标题:Molecular design of radiocopper-labelled Affibody molecules
  • 本地全文:下载
  • 作者:Vladimir Tolmachev ; Tove J. Grönroos ; Cheng-Bin Yim
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:6542
  • DOI:10.1038/s41598-018-24785-2
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:Cu-CB-TE2A-GEEE-ZHER2:342 was 16 ± 6%ID/g and tumor-to-blood ratio was 181 ± 52. In conclusion, a combination of the cross-bridged CB-TE2A chelator and Gly-Glu-Glu-Glu spacer is preferable for radiocopper labelling of Affibody molecules and, possibly, other scaffold proteins having high renal re-absorption.
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