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  • 标题:Myotube elasticity of an amyotrophic lateral sclerosis mouse model
  • 本地全文:下载
  • 作者:Béla Varga ; Marta Martin-Fernandez ; Cécile Hilaire
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:5917
  • DOI:10.1038/s41598-018-24027-5
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:expressing myotubes, where a significant shift of thin population towards higher elastic modulus values was observed. We provide evidence that SOD1 mutant induces structural changes that occurs very early in muscle development and well before symptomatic stage of the disease. These findings could significantly contribute to the understanding of the role of skeletal muscle in ALS pathogenesis.
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