首页    期刊浏览 2024年11月08日 星期五
登录注册

文章基本信息

  • 标题:Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels
  • 本地全文:下载
  • 作者:Jonathan M. Beckel ; Néstor Más Gómez ; Wennan Lu
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:5726
  • DOI:10.1038/s41598-018-23877-3
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:was abolished by removing extracellular ATP with apyrase, suggesting ATP release by poly(I:C) increased cellular signaling. Starvation but not rapamycin prevented lysosomal ATP release. In summary, stimulation of TLR3 triggers lysosomal alkalization and release of lysosomal ATP through activation of TRPML1; this links innate immunity to purinergic signaling via lysosomal physiology, and suggests even scrambled siRNA can influence these pathways.
国家哲学社会科学文献中心版权所有