文章基本信息

标题：SMAD6 overexpression leads to accelerated myogenic differentiation of LMNA mutated cells
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作者：Alexandre Janin ; Delphine Bauer ; Francesca Ratti 等
期刊名称：Scientific Reports
电子版ISSN：2045-2322
出版年度：2018
卷号：8
期号：1
页码：5618
DOI：10.1038/s41598-018-23918-x
语种：English
出版社：Springer Nature
摘要：myoblasts premature differentiation and can be rescued by downregulating Smad6 expression. Finally, we showed that BMP4 pathway defects are also present in myoblasts from human patients carrying different heterozygous LMNA mutations.