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  • 标题:A comparative analysis of rod bipolar cell transcriptomes identifies novel genes implicated in night vision
  • 本地全文:下载
  • 作者:Sasha M. Woods ; Edward Mountjoy ; Duncan Muir
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:5506
  • DOI:10.1038/s41598-018-23901-6
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:mouse retina (that lacks RBCs) to derive the RBC transcriptome. We found that genes expressed by adult RBCs are mainly involved in synaptic structure and signalling, whereas genes that influence RBC development are also involved in the cell cycle and transcription/translation. By comparing our data with other published retinal and bipolar cell transcriptomes (where we identify RBCs by the presence of Prkca and/or Pcp2 transcripts), we have derived a consensus for the adult RBC transcriptome. These findings ought to facilitate further research into physiological mechanisms underlying mammalian night vision as well as proposing candidate genes for patients with inherited causes of night blindness.
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