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  • 标题:Morphometric analysis of spread platelets identifies integrin αIIbβ3-specific contractile phenotype
  • 本地全文:下载
  • 作者:Sebastian Lickert ; Simona Sorrentino ; Jan-Dirk Studt
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:5428
  • DOI:10.1038/s41598-018-23684-w
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:mechanotransduction fundamentally determines the adoption of a bipolar phenotype associated with contraction. Super-resolution microscopy and electron microscopies further confirmed the stress fibre-like contractile actin architecture. For the first time, our assay allows the unbiased and quantitative assessment of platelet morphologies and could help to identify defective platelet behaviour contributing to elusive bleeding phenotypes.
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