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  • 标题:An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis
  • 本地全文:下载
  • 作者:José Roberto Fogaça de Almeida ; Grasielle Pereira Jannuzzi ; Gilberto Hideo Kaihami
  • 期刊名称:Scientific Reports
  • 电子版ISSN:2045-2322
  • 出版年度:2018
  • 卷号:8
  • 期号:1
  • 页码:4192
  • DOI:10.1038/s41598-018-22709-8
  • 语种:English
  • 出版社:Springer Nature
  • 摘要:T cells and higher levels of IFN-γ, IL-17A and IL-1β characterizing a strong cellular immune response. This immune environment induced a higher number of neutrophils in lesions that are associated with fungus clearance. These results indicated that the ZR8 peptide induces a protective immune response against subcutaneous sporotrichosis and is a vaccine candidate against S. brasiliensis infection.
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